CAS No.50-23-7 Hydrocortisone

Hydrocortisone

Identification
Name Hydrocortisone
CAS Registry Number 50-23-7
Synonyms 11,17a,21-Trihydroxy-4-pragnene-3,20-dione;11-beta,17,21-trihydroxypregn-4-ene-3,20-dione;11beta,17,21-Trihydroxypregn-4-ene-3,20-dione;11-beta,17-alpha,21-trihydroxy-4-pregnene-3,20-dione;11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione;11-beta,17-alpha-trihydroxypregnane-4-ene-3,20-dione;11-beta-hydrocortisone;11beta-Hydrocortisone
Molecular Structure Hydrocortisone   50-23-7
Molecular Formula C21H30O5
Molecular Weight 362.46
mp: 211-214 ℃(lit.)
Hazard Codes: Details
Risk Statements: 63-62-40
Safety Statements: 36/37-45-36-22

CAS 50-23-7 Wiki / 50-23-7 MSDS

Hydrocortisone
Cortisol2.svg
Cortisol-3D-balls.png
Clinical data
Trade names Cortef, Solu-Cortef, others[1]
AHFS/Drugs.com Monograph
MedlinePlus a682206
License data
  • US FDA: Hydrocortisone
Pregnancy
category
  • AU: A
  • US: C (Risk not ruled out)
Routes of
administration
By mouth (tablets), intravenous, topical, rectal
ATC code
  • A01AC03 (WHO) A07EA02 (WHO) C05AA01 (WHO) D07AA02 (WHO) H02AB09 (WHO) S01BA02 (WHO) S02BA01 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only) For oral use. S3(Pharmacist only medication) for 1% topical preparations. S2(Pharmacy medicine) for 0.5% topical preparations.
  • UK: POM (Prescription only)
  • US: OTC for topical administration; Rx-only for oral tablets, rectal use and intravenous therapy
Identifiers
Synonyms Cortisol; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione
CAS Number
  • 50-23-7 YesY
PubChem CID
  • 5754
DrugBank
  • DB00741 N
ChemSpider
  • 5551 YesY
UNII
  • WI4X0X7BPJ
KEGG
  • D00088 YesY
ChEBI
  • CHEBI:17650 YesY
ChEMBL
  • CHEMBL389621 YesY
Chemical and physical data
Formula C21H30O5
Molar mass 362.460 g/mol
3D model (JSmol)
  • Interactive image
 NYesY (what is this?)  (verify)

Hydrocortisone, sold under a number of brand names including Cortef, is the name for the hormone cortisol when supplied as a medication.[2] Uses includes conditions such as adrenocortical insufficiency, adrenogenital syndrome, high blood calcium, thyroiditis, rheumatoid arthritis, dermatitis, asthma, and COPD.[1] It is the treatment of choice for adrenocortical insufficiency.[3] It can be given by mouth or by injection.[1] Stopping treatment after long-term use should be done slowly.[1]

Side effects may include mood changes, increased risk of infection, and swelling.[1] With long-term use common side effects include osteoporosis, upset stomach, physical weakness, easy bruising, and yeast infections.[1] While used, it is unclear if it is safe during pregnancy.[4] It works as an antiinflammatory and by immune suppression.[1]

Hydrocortisone was discovered in 1955.[5] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[6] It is available as a generic medication.[1] The wholesale cost in the developing world is about 0.27 USD per day as of 2014 for the form taken by mouth.[7] In the United States it costs less than 25 USD for a typical month of treatment.[3]