CAS No.50-52-2 Thioridazine

Thioridazine

Identification
Name Thioridazine
CAS Registry Number 50-52-2
Synonyms THIORIDAZINE;10-((1-methyl-2-piperidyl)ethyl)-2-(methylthio)-phenothiazin;10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylthio)-10h-phenothiazin;10-(2-(1-methyl-2-piperidyl)ethyl)-2-(methylthio)-phenothiazin;10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine;10-[2-(1-Methyl-2-piperdiyl)ethyl]-2-(methylthio)phenothiazine;10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine;10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-
Molecular Structure Thioridazine   50-52-2
Molecular Formula C21H26N2S2
Molecular Weight 370.57

CAS 50-52-2 Wiki / 50-52-2 MSDS

Thioridazine
Thioridazine.svg
Clinical data
AHFS/Drugs.com Consumer Drug Information
MedlinePlus a682119
License data
  • US DailyMed: 9c4bedb4-2d59-4fcd-aad7-fce988cd96d8
  • US FDA: Thioridazine
Pregnancy
category
  • AU: C
  • US: C (Risk not ruled out)
Routes of
administration
Oral
ATC code
  • N05AC02 (WHO)
Legal status
Legal status
  • Withdrawn by the manufacturer worldwide[1]
Pharmacokinetic data
Bioavailability incomplete
Metabolism hepatic (at least partly mediated by CYP2D6)
Biological half-life 21-24 hours[2]
Excretion faeces
Identifiers
CAS Number
  • 50-52-2 YesY
PubChem CID
  • 5452
IUPHAR/BPS
  • 100
DrugBank
  • DB00679 YesY
ChemSpider
  • 5253 YesY
UNII
  • N3D6TG58NI
KEGG
  • D00373 YesY
ChEBI
  • CHEBI:9566 YesY
ChEMBL
  • CHEMBL479 YesY
ECHA InfoCard 100.000.041
Chemical and physical data
Formula C21H26N2S2
Molar mass 370.577
3D model (JSmol)
  • Interactive image
  (verify)

Thioridazine (Mellaril or Melleril) is a piperidine typical antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis. The branded product was withdrawn worldwide in 2005 because it caused severe cardiac arrhythmias. However, generic versions are still available in the US.[1]