CAS No.50-55-5 Reserpine


Name Reserpine
CAS Registry Number 50-55-5
Synonyms RESERPINE;3,4,5-TRIMETHOXYBENZOYL METHYL RESERPATE;11,17-DIMETHOXY-18-[(3,4,5-TRIMETHOXYBENZOYL)OXY]YOHIMBAN-16-CARBOXYLIC ACID METHYL ESTER;METHYL RESERPATE;METHYL RESERPATE 3,4,5-TRIMETHOXYBENZOIC ACID ESTER;l -Carpserp;(3beta,16beta,17alpha,18beta,20alpha)-methyleste;,methylester,(3beta,16beta,17alpha,18beta,20alpha)-
Molecular Structure Reserpine   50-55-5
Molecular Formula C33H40N2O9
Molecular Weight 608.68
mp: ~265 ℃ (dec.)
Hazard Codes: Details
Risk Statements: 22-67-36-10
Safety Statements: 22-36/37/39-26
RIDADR: 3077

CAS 50-55-5 Wiki / 50-55-5 MSDS

Clinical data
AHFS/ Consumer Drug Information
MedlinePlus a601107
License data
  • US FDA: Reserpine
  • C
Routes of
ATC code
  • C02AA02 (WHO)
Legal status
Legal status
  • Rx-only (banned/discontinued in some countries)
Pharmacokinetic data
Bioavailability 50%
Metabolism gut/liver
Biological half-life phase 1 = 4.5h,
phase 2 = 271h,
average = 33h
Excretion 62% feces / 8% urine
CAS Number
  • 50-55-5 YesY
PubChem CID
  • 5770
  • 4823
  • DB00206 YesY
  • 5566 YesY
  • 8B1QWR724A
  • D00197 YesY
  • CHEBI:28487 YesY
  • CHEMBL772 YesY
ECHA InfoCard 100.000.044
Chemical and physical data
Formula C33H40N2O9
Molar mass 608.68 g/mol
3D model (JSmol)
  • Interactive image

Reserpine (also known by trade names Raudixin, Serpalan, Serpasil) is an indole alkaloid,[1] antipsychotic, and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms, although because of the development of better drugs for these purposes and because of its numerous side-effects, it is rarely used today.[2] The antihypertensive actions of reserpine are a result of its ability to deplete catecholamines (among other monoamine neurotransmitters) from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral vascular resistance.[3]

Reserpine-mediated depletion of monoamine neurotransmitters in the synapses is often cited as evidence to the theory that depletion of the monoamine neurotransmitters causes subsequent depression in humans (c.f. monoamine hypothesis). However, this claim is not without controversy. The reserpine-induced depression is considered by some researchers to be a myth, while others claim that teas made out of the plant roots containing reserpine have a calming, sedative action that can actually be considered antidepressant.[4] Notably, reserpine was the first compound shown to be an effective antidepressant in a randomized placebo-controlled trial.[5]

Moreover, reserpine has a peripheral action in many parts of the body, resulting in a preponderance of the effects of the cholinergic part of the autonomous nervous system on the GI tract, smooth muscles, blood vessels, etc.