CAS No.50-57-7 Lypressin


Name Lypressin
CAS Registry Number 50-57-7
Synonyms (8-lysine)vasopressin;8-l-lysine-vasopressi;8-l-lysinevasopressin;diapid;l-lysinevasopressin;lysinepitressin;postacton;syntopressin
Molecular Structure Lypressin   50-57-7
Molecular Formula C46H65N13O12S2
Molecular Weight 1056.22
Hazard Codes: Details
Risk Statements: 20
Safety Statements: 36

CAS 50-57-7 Wiki / 50-57-7 MSDS

Vasopressin labeled.png
Arginine vasopressin3d.png
Pronunciation /ˌvzˈprsən/
Physiological data
Source tissues Supraoptic nucleus; Paraventricular nucleus of hypothalamus
Target tissues System-wide
Receptors V1A, V1B, V2, OXTR
Agonists Felypressin, Desmopressin
Antagonists Diuretics
Metabolism Predominantly in the liver and kidneys
Pharmacokinetic data
Protein binding 1%
Metabolism Predominantly in the liver and kidneys
Biological half-life 10-20 minutes
Excretion Urine
Synonyms Arginine Vasopressin; Argipressin
CAS Number
  • 11000-17-2 YesY
PubChem CID
  • 644077
  • 2168
  • DB00067 YesY
  • 559126 YesY
  • Y4907O6MFD
  • D00101 YesY
  • CHEBI:9937 YesY
  • CHEMBL373742 YesY
Chemical and physical data
Formula C46H65N15O12S2
Molar mass 1,084.24 g·mol−1
3D model (JSmol)
  • Interactive image
Density 1.6±0.1 g/cm3
Arginine vasopressin3d.png
Aliases AVP, ADH, ARVP, AVP-NPII, AVRP, VP, arginine vasopressin, Vasopressin
External IDs OMIM: 192340 MGI: 88121 HomoloGene: 417 GeneCards: AVP
Gene location (Human)
Chromosome 20 (human)
Chr. Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for AVP
Genomic location for AVP
Band No data available Start 3,082,556 bp[1]
End 3,084,724 bp[1]
RNA expression pattern
PBB GE AVP 207848 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 20: 3.08 – 3.08 Mb Chr 20: 130.58 – 130.58 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Vasopressin, also known as antidiuretic hormone (ADH), is a neurohypophysial hormone found in most mammals which is also used as a medication. In most species it contains arginine and is thus also called arginine vasopressin (AVP) or argipressin.[5] Its two primary functions are to retain water in the body and to constrict blood vessels.[6] Vasopressin regulates the body's retention of water by acting to increase water reabsorption in the kidney's collecting ducts, the tubules which receive the very dilute urine produced by the functional unit of the kidney, the nephrons.[7][8]

Vasopressin is a peptide hormone that increases water permeability of the kidney's collecting duct and distal convoluted tubule by inducing translocation of aquaporin-CD water channels in the plasma membrane of collecting duct cells.[9] It also increases peripheral vascular resistance, which in turn increases arterial blood pressure. It plays a key role in homeostasis, by the regulation of water, glucose, and salts in the blood. It is derived from a preprohormone precursor that is synthesized in the hypothalamus and stored in vesicles at the posterior pituitary.

Most of vasopressin is stored in the posterior pituitary to be released into the bloodstream. However, some AVP may also be released directly into the brain, and accumulating evidence suggests it plays an important role in social behavior, sexual motivation and pair bonding, and maternal responses to stress.[10] It has a very short half-life between 16–24 minutes.[8]