CAS No.50-57-7 Lypressin

Lypressin

Identification
Name Lypressin
CAS Registry Number 50-57-7
Synonyms (8-lysine)vasopressin;8-l-lysine-vasopressi;8-l-lysinevasopressin;diapid;l-lysinevasopressin;lysinepitressin;postacton;syntopressin
Molecular Structure Lypressin   50-57-7
Molecular Formula C46H65N13O12S2
Molecular Weight 1056.22
Hazard Codes: Details
Risk Statements: 20
Safety Statements: 36

CAS 50-57-7 Wiki / 50-57-7 MSDS

Vasopressin
Vasopressin labeled.png
Arginine vasopressin3d.png
Clinical data
Pronunciation /ˌvzˈprsən/
Synonyms Arginine Vasopressin; Argipressin
Physiological data
Source tissues Supraoptic nucleus; Paraventricular nucleus of hypothalamus
Target tissues System-wide
Receptors V1A, V1B, V2, OXTR
Agonists Felypressin, Desmopressin
Antagonists Diuretics
Metabolism Predominantly in the liver and kidneys
Pharmacokinetic data
Protein binding 1%
Metabolism Predominantly in the liver and kidneys
Biological half-life 10-20 minutes
Excretion Urine
Identifiers
CAS Number
  • 11000-17-2 YesY
PubChem CID
  • 644077
IUPHAR/BPS
  • 2168
DrugBank
  • DB00067 YesY
ChemSpider
  • 559126 YesY
UNII
  • Y4907O6MFD
KEGG
  • D00101 YesY
ChEBI
  • CHEBI:9937 YesY
ChEMBL
  • CHEMBL373742 YesY
Chemical and physical data
Formula C46H65N15O12S2
Molar mass 1,084.24 g·mol−1
3D model (JSmol)
  • Interactive image
Density 1.6±0.1 g/cm3
AVP
Arginine vasopressin3d.png
Identifiers
Aliases AVP, ADH, ARVP, AVP-NPII, AVRP, VP, arginine vasopressin, Vasopressin
External IDs OMIM: 192340 MGI: 88121 HomoloGene: 417 GeneCards: AVP
Gene location (Human)
Chromosome 20 (human)
Chr. Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for AVP
Genomic location for AVP
Band 20p13 Start 3,082,556 bp[1]
End 3,084,724 bp[1]
RNA expression pattern
PBB GE AVP 207848 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000490

NM_009732

RefSeq (protein)

NP_000481

NP_033862

Location (UCSC) Chr 20: 3.08 – 3.08 Mb Chr 20: 130.58 – 130.58 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Vasopressin, also named antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin,[5] is a hormone synthesized as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP. It then travels down the axon of that cell, which terminates in the posterior pituitary, and is released from vesicles into the circulation in response to extracellular fluid hypertonicity (hyperosmolality). AVP has two primary functions. First, it increases the amount of solute-free water reabsorbed back into the circulation from the filtrate in the kidney tubules (nephrons). Second, AVP constricts arterioles, which increases peripheral vascular resistance and raises arterial blood pressure.[6] [7][8]

A third function is possible. Some AVP may be released directly into the brain from the hypothalamus, and may play an important role in social behavior, sexual motivation and pair bonding, and maternal responses to stress.[9]

It has a very short half-life, between 16–24 minutes.[8]

Vasopressin is available for use as a medication.