CAS No.60-54-8 Tetracycline

Tetracycline

Identification
Name Tetracycline
CAS Registry Number 60-54-8
Synonyms 12,12a-pentahydroxy-6-methyl-1,11-dioxo-1;4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-Naphthacenecarboxamide;4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-4-(dimethylamino)-4;6-methyl-1,11-dioxy-2-naphthacenecarboxamide;abramycin;abricycline;achromycin(naphthacenederivative);achromycin(naphthracenederivatives)
Molecular Structure Tetracycline   60-54-8
Molecular Formula C22H26N2O9
Molecular Weight 462.45
mp: 175-177 ℃(lit.)
Hazard Codes: Details
Risk Statements: 22-36/37/38
Safety Statements: 22-36-26

CAS 60-54-8 Wiki / 60-54-8 MSDS

Tetracycline
Tetracycline skeletal.svg
Clinical data
Pronunciation /ˌtɛtrəˈskln/
Trade names Sumycin, others
AHFS/Drugs.com Monograph
MedlinePlus a682098
License data
  • US FDA: Tetracycline
Pregnancy
category
  • AU: D
  • US: D (Evidence of risk)
Routes of
administration
By mouth
ATC code
  • A01AB13 (WHO) D06AA04 (WHO) J01AA07 (WHO) S01AA09 (WHO) S02AA08 (WHO) S03AA02 (WHO) QG01AA90 (WHO) QG51AA02 (WHO) QJ51AA07 (WHO)
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability 75%
Metabolism Not metabolized
Biological half-life 8–11 hours, 57–108 hours (kidney impairment)
Excretion Urine (>60%), feces
Identifiers
CAS Number
  • 60-54-8 YesY
    64-75-5 (hydrochloride)
PubChem CID
  • 643969
DrugBank
  • DB00759 YesY
ChemSpider
  • 10257122 YesY
UNII
  • F8VB5M810T
KEGG
  • D00201 YesY
ChEBI
  • CHEBI:27902 YesY
ChEMBL
  • CHEMBL1440 YesY
ECHA InfoCard 100.000.438
Chemical and physical data
Formula C22H24N2O8
Molar mass 444.435 g/mol
3D model (JSmol)
  • Interactive image
  (verify)

Tetracycline, sold under the brand name Sumycin among others, is an antibiotic used to treat a number of infections. This includes acne, cholera, brucellosis, plague, malaria, and syphilis. It is taken by mouth.[1]

Common side effects include vomiting, diarrhea, rash, and loss of appetite. Other side effects include poor tooth development if used by children less than eight years of age, kidney problems, and sunburning easily. Use during pregnancy may harm the baby. Tetracycline is in the tetracyclines family of medications. It works by blocking the bacteria's ability to make protein.[1]

Tetracycline was patented in 1953 and came into commercial use in 1978.[2] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[3] Tetracycline is available as a generic medication.[1] The wholesale cost in the developing world is about 0.35 to 1.78 USD for a course of treatment.[4] In the United States a course of treatment typically costs less than 25 USD.[5] Tetracycline was originally made from the bacteria Streptomyces.[1]