CAS No.60-80-0 Antipyrine

Antipyrine

Identification
Name Antipyrine
CAS Registry Number 60-80-0
Synonyms 1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-on;1,5-Dimethyl1-2-phenyl-3-pyrazolone;1,5-Dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one;1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one;1-Pheny-1-2,3-dimethylpyrazolone-[5],1,2-Di-hydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one;1-Phenyl-2,3-dimethyl-5-pyrazolone;1-Phenyl-2,3-dimethylpyrazole-5-one;3-Antipyrine
Molecular Structure Antipyrine   60-80-0
Molecular Formula C11H12N2O
Molecular Weight 188.23
mp: 109-111 ℃(lit.)
Hazard Codes: Details
Risk Statements: 22-36/37/38
Safety Statements: 26-36-37/39
RIDADR: 3249

CAS 60-80-0 Wiki / 60-80-0 MSDS

Phenazone
Phenazone2DCSD.svg
Clinical data
Synonyms analgesine, antipyrine
ATC code
  • N02BB01 (WHO) S02DA03 (WHO)
Pharmacokinetic data
Biological half-life 12 hours
Identifiers
CAS Number
  • 60-80-0 YesY
PubChem CID
  • 2206
DrugBank
  • DB01435 YesY
ChemSpider
  • 2121 YesY
UNII
  • T3CHA1B51H
KEGG
  • D01776 YesY
ChEBI
  • CHEBI:31225 YesY
ChEMBL
  • CHEMBL277474 YesY
ECHA InfoCard 100.000.442
Chemical and physical data
Formula C11H12N2O
Molar mass 188.2258g/mol
3D model (JSmol)
  • Interactive image
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Phenazone (INN and BAN; also known as phenazon, antipyrine (USAN), or analgesine) is an analgesic, a nonsteroidal anti-inflammatory drug (NSAID) and an antipyretic. It was first synthesized by Ludwig Knorr in 1887.[1][2]:26–27 Phenazone is synthesized[3] by condensation of phenylhydrazine and ethyl acetoacetate under basic conditions and methylation of the resulting intermediate compound 1-phenyl-3-methylpyrazolone[4] with dimethyl sulfate or methyl iodide. It crystallizes in needles which melt at 156 °C. Potassium permanganate oxidizes it to pyridazine tetracarboxylic acid. Phenazone has an elimination half life of about 12 hours.[5] Indication: Used to relieve pain and fever. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.[6]