CAS No.90-04-0 o-Anisidine


Name o-Anisidine
CAS Registry Number 90-04-0
Synonyms O-AMINOPHENOL METHYL ETHER;O-AMINOANISOLE;O-ANISIDINE;ORTHO ANISIDINE;O-METHOXYANILINE;2-Methoxy-1-aminobenzene;2-methoxy-benzenamin;2-Methoxybenzenamine
Molecular Structure o-Anisidine  90-04-0
Molecular Formula C7H9NO
Molecular Weight 123.15
mp: 3-6 ℃(lit.)
Hazard Codes: Details
Risk Statements: 45-23/24/25-68
Safety Statements: 53-45
RIDADR: UN 2431 6.1/PG 3
HS Code: 29222200

CAS 90-04-0 Wiki / 90-04-0 MSDS

Skeletal formula of o-anisidine
Ball-and-stick model of the o-anisidine molecule
Preferred IUPAC name
Other names
o-Anisidine (no longer recommended[1])
CAS Number
  • 90-04-0 YesY
3D model (JSmol)
  • Interactive image
  • 13860775 YesY
ECHA InfoCard 100.001.785
EC Number 201-963-1
  • C19191 YesY
UN number 2431
Chemical formula
Molar mass 123.16 g·mol−1
Appearance Yellow liquid, turns brown upon exposure to air
Density 1.0923 g/cm3
Melting point 6.2 °C (43.2 °F; 279.3 K)
Boiling point 224 °C (435 °F; 497 K)
Solubility in water
1.5 g/100 ml
Solubility soluble in ethanol, diethyl ether, acetone, benzene
Magnetic susceptibility (χ)
-80.44·10−6 cm3/mol
Main hazards potential occupational carcinogen[3]
EU classification (DSD) (outdated)
Toxic (T)
Carc. Cat. 2
Muta. Cat. 3
R-phrases (outdated) R45, R23/24/25, R68
S-phrases (outdated) S53, S45
NFPA 704
Flammability code 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g., canola oilHealth code 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g., chloroformReactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogenSpecial hazards (white): no codeNFPA 704 four-colored diamond
Flash point 118 °C (244 °F; 391 K) (open cup)
415 °C (779 °F; 688 K)
Lethal dose or concentration (LD, LC):
LD50 (median dose)
2000 mg/kg (rat, oral)
1400 mg/kg (mouse, oral)
870 mg/kg (rabbit, oral)[4]
US health exposure limits (NIOSH):
PEL (Permissible)
TWA 0.5 mg/m3 [skin][3]
REL (Recommended)
 : Ca TWA 0.5 mg/m3 [skin][3]
IDLH (Immediate danger)
50 mg/m3[3]
Related compounds
Related compounds
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

o-Anisidine (2-anisidine) is a yellow liquid with a melting point of −1 to 5 °C and a density of 1.09 g/cm3. The vapor pressure is 0.05 mbar at 20 °C but increases greatly with temperature. It has an aromatic smell and is well absorbed by inhalation, oral ingestion and skin contact. o-Anisidine is a very toxic agent that causes blood, enzyme and nerve damage with cyanosis and the danger of suffocation.[3] The agent is an experimental carcinogen and is strongly suspected to be a human carcinogen also. o-Anisidine has dangerous pollutant properties for water. Non-wastewaters from the production of dyes containing o-Anisidine are listed as RCRA hazardous waste, with the code K181.[5] o-Anisidine is used in the manufacture of dyes. Workers in the dye industry may be occupationally exposed to it. Acute (short-term) exposure to o-anisidine results in skin irritation in humans. Workers exposed to o-anisidine by inhalation for 6 months developed headaches, vertigo, and effects on the blood. Animal studies have reported effects on the blood from chronic (long-term) dermal exposure to o-anisidine. No information is available on the reproductive, developmental, or carcinogenic effects of o-anisidine in humans. Animal studies have reported tumors of the urinary bladder from oral exposure to o-anisidine. EPA has not classified o-anisidine for carcinogenicity. The International Agency for Research on Cancer (IARC) has classified o-anisidine as a Group 2B, possible human carcinogen.[6]