CAS No.90-34-6 Primaquine


Name Primaquine
CAS Registry Number 90-34-6
Molecular Structure Primaquine  90-34-6
Molecular Formula C15H21N3O
Molecular Weight

CAS 90-34-6 Wiki / 90-34-6 MSDS

Clinical data
Synonyms primaquine phosphate
AHFS/ Monograph
MedlinePlus a607037
Routes of
by mouth
ATC code
  • P01BA03 (WHO)
Legal status
Legal status
  • UK: Unlicensed
  • US: ℞-only
Pharmacokinetic data
Bioavailability 96%[1]
Metabolism Liver
Biological half-life 6 hours
Excretion ?
CAS Number
  • 90-34-6 YesY
PubChem CID
  • 4908
  • DB01087 YesY
  • 4739 YesY
  • MVR3634GX1
  • D08420 YesY
  • CHEBI:8405 YesY
  • CHEMBL506 YesY
ECHA InfoCard 100.001.807
Chemical and physical data
Formula C15H21N3O
Molar mass 259.347 g/mol
3D model (JSmol)
  • Interactive image
Chirality Racemic mixture

Primaquine is a medication used to treat and prevent malaria and to treat Pneumocystis pneumonia.[2] Specifically it is used for malaria due to Plasmodium vivax and Plasmodium ovale along with other medications and for prevention if other options cannot be used.[2] It is an alternative treatment for Pneumocystis pneumonia together with clindamycin.[2][3] It is taken by mouth.[2]

Common side effects include nausea, vomiting, and stomach cramps.[2][4] Primaquine should not be given to people with glucose-6-phosphate dehydrogenase (G6PD) deficiency due to the risk of red blood cell breakdown.[4] It is often recommended that primaquine not be used during pregnancy.[5][6] It may be okay in breastfeeding when the baby is known not to have G6PD deficiency.[6] The mechanisms of action is not entirely clear but is believed to involve effects on the malaria parasites DNA.[2]

Primaquine was first made in 1946.[3] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[7] It is available as a generic medication.[2] The wholesale cost in the developing world is 0.04 to 0.11 USD per day.[8] In the United States a typical course of treatment is 50 to 100 USD.[5]